Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Written consent of the participant after being informed

• At least 18 years of age

• End stage kidney disease patient undergoing hemodialysis

• Dry weight stable for a minimum of one month

• Interdialytic weight gain of \>2 liters in the short interdialytic interval

Locations
Other Locations
Austria
Medical University of Graz
RECRUITING
Graz
Contact Information
Primary
Alexander H Kirsch
alexander.kirsch@medunigraz.at
+43316385
Time Frame
Start Date: 2022-11-02
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 32
Treatments
Active_comparator: Sequential HD - Conventional HD
In sequence A patients will be treated with sequential HD first, for a total of 8 session and then switched to a conventional HD schedule for another 8 sessions.
Active_comparator: Conventional HD - Sequential HD
In sequence A patients will be treated with conventional HD first, for a total of 8 session and then switched to a sequential HD schedule for another 8 sessions.
Sponsors
Leads: Medical University of Graz

This content was sourced from clinicaltrials.gov